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Estrogen is thought of as a hormone that is involved in female reproduction, but it also occurs in males in smaller amounts and affects the growth, differentiation and function of many tissues in the body. Estrogen is a term that is used to collectively describe the hormones estradiol, estrone and estriol. In the body, estrogens circulate mainly bound to the sex hormone binding globulin (SHBG) and only unbound (or “free”) estrogens can enter cells and lead to biological effects.1 Various lifestyle and environmental factors can influence the production, binding, metabolism and function of estrogen in men and women.